Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury.

Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer’s Disease

Biometal dyshomeostasis and toxic metal accumulation are common features in many neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease. The neurotoxic effects of metal imbalance are generally associated with reduced enzymatic activities, elevated protein aggregation and oxidative stress in the central nervous system, in which a cascade of...

Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer's Disease Patients

Increased interest regarding the biometal mechanisms of action and the pathways in which they have regulatory roles was lately observed. Particularly, it was shown that biometal homeostasis dysregulation may lead to neurodegeneration including Alzheimer's disease, Parkinson disease, or prion protein disease, since important molecular signaling mechanisms in brain functions implicate both oxidat...

Towards Understanding Plant Response to Heavy Metal Stress

Metals like zinc, iron and copper are essential micronutrients required for a wide range of physiological processes in all plant organs for the activities of various metal-dependent enzymes and proteins. However, they can also be toxic at elevated levels. Metals like arsenic, mercury, cadmium and lead are nonessential and potentially highly toxic. Once the cytosolic metal concentration in plant...

Mercury induces tight junction alterations and paracellular transport in colon epithelial cells through oxidative stress and thiol-redox dysregulation – Protection by novel lipid-soluble thiol antioxidant and heavy metal chelator, N,N’-bis-2-(mercaptoethyl)isophthalamide ( NBMI)

Bioaccumulation of heavy metals in muscle tissue of fishes from selected aquaculture ponds in east Kolkata wetlands

Heavy metals i.e. Copper (Cu), Zinc (Zn), Manganese (Mn), Iron (Fe), Cadmium (Cd), Nickel (Ni), Mercury (Hg) and Arsenic (As) were analyzed in 35 samples of the fish muscle, from East Kolkata Wetlands (EKW). The concentration of heavy metals was in order of, Fe > Zn > Cu > Mn > Ni > As > Hg > Cd. The essential metals, such as iron, zinc, copper and manganese were in higher concentrations and, t...